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Scientists Rewind the Cellular Biological Clock by Over 30 Years

Published Mon, Apr 18 2022 14:17 pm
by The Silicon Trend

 

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Scientists Reprogram Ageing Skin Cells to Rejuvenate Them

Researchers at Babraham Institute have created a novel technique for rejuvenating skin cells - allowing them to rewind the cellular biological clock by over 30 years according to molecular measures, which is notably longer than previous techniques. They have been able to partially restore older cell functions and rejuvenate the molecular actions of biological age.

As we age, our cells' potential to work reduces, and the genome accumulates aging marks. Regenerative biology targets repairing or replacing cells, including the older ones - and the most effective tool in this field is our potential to develop induced stem cells.

 

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The New Technique: Maturation Phase Transient Reprogramming

The first scientist to turn normal cells into stem cells that had the extraordinary potential to create any cell type was Shinya Yamanaka in 2007. The entire stem cell reprogramming process takes approximately 50 days using four key molecules known as the Yamanaka factors. 

The new technique - maturation phase transient reprogramming, exposes cells to the factors for just 13 days. At this point, age-based transformations are eradicated, and the cells have temporarily lost their identity. Next, the partially reprogrammed cells were given time to develop under normal conditions, to monitor whether their specific skin cell function returned.

Genome analysis illustrated that the cells had regained markers trait of skin cells (fibroblast), which was confirmed by monitoring collagen production in reprogrammed cells. A group leader in the Epigenetics research program, Prof Wolf Reik, said the new technique has fascinating implications. They may be able to determine genes that can rejuvenate without reprogramming and explicitly target those minimizing aging effects. This method promises valuable discoveries that lead to a superior therapeutic horizon.

 

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